Some of the most notable open-source software projects for AMD64 range from high-performance computing and enterprise applications to small business and consumer software. AMD recognizes the support from leading Linux distributors Red Hat, SUSE LINUX, Mandrakesoft and Turbolinux; Linux community projects like cAos, Debian, Fedora, Gentoo and Tao; and, UNIX projects NetBSD, FreeBSD and OpenBSD. In addition, open-source projects that continue to be optimized for AMD64 include the GNU Compiler Collection and debuggers, MPICH, as well as LinuxBIOS for cluster configurations, and Apache, Sendmail and MySQL IT infrastructure applications.

Linux applications run unmodified on Solaris OS x86 Platform Edition through Java technology, and common interfaces and tools. Solaris OS x86 Platform Edition is specifically optimized to run on AMD Opteron™ processor-based systems.

AMD is a member of the Open Source Development Labs (OSDL). OSDL is a global consortium dedicated to accelerating the growth and adoption of Linux and the support of open-source solutions in the data center and on the desktop.